(2017). Pycnogenol (125 mg/day) had the same effects in another study of 48 people with diabetes and high blood pressure. Asthma is caused by inflammation in the lungs, which makes it hard to breathe. 1 Anti-Aging Beverage, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, What Is a Marionberry? Perimenopausal women who took pine bark extract for eight weeks noticed decreased cholesterol and triglyceride levels. Based on another study of 6 trained and 7 untrained people, an antioxidant combination product containing Pycnogenol (Lactaway) may increase endurance. In a study of 76 people with allergic asthma, Pycnogenol (100 mg/day) added to conventional corticosteroid inhalers for 6 months helped 55% of them reduce inhaler use frequency and dosage. Helps Treat Erectile Dysfunction. Taking pycnogenol daily for 2 months seems to slow or prevent further worsening of retinal disease caused by diabetes, atherosclerosis, or other diseases. . Pycnogenol can help control blood pressure, which helps improve overall heart health. Pycnogenol may help reduce symptoms of melasma, a form of hyperpigmentation, possibly because it protects against UV rays. Learn more. In addition to general healthy eating, some specific vitamins and minerals may help improve ADHD. Along with the rest of the crew, he developed symptoms of vitamin-C deficiency. They were treated with 200 mg of Pycnogenol daily or with placebo. Pycnogenol (100 mg/day) supplementation may decrease symptoms of the common cold and speed up recovery, according to a clinical trial of 146 people. Pycnogenol also treatment improved blood vessel function. A study of 66 healthy adults found that Pycnogenol may reduce the number of leg cramps experienced [11]. As I mentioned, pine bark extract is superior when it comes to antioxidants. Low-dose Pycnogenol (30 mg/day) may reduce pain in pregnant women, particularly hip, joint, lower back, groin, and calf cramps in the third trimester [71]. Unlike drug manufacturers, the makers of supplements dont have to show their products are safe or effective before selling them on the market. Because of its anti-inflammatory effects, nattokinase has been used to help with pain from arthritis, including that of rheumatoid arthritis. 10 Day Erection Delay Sex Pills. Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications. Pycnogenol is considered possibly safe when taken orally or when applied topically as a cream or ointment. ", Mayo Clinic: High blood pressure (hypertension)., Panminerva Medica: "Pycnogenol improvements in asthma management. We avoid using tertiary references. Blood clots form as a result of platelet aggregation, which is the platelets in the blood clumping together. Prenatal nutrition can be confusing. One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. The crew fell extremely ill from scurvy, an extreme lack of vitamin C. Cartiers crew crossed paths with a Quebec Indian who encouraged them to drink a tea made from pine bark and needles. It also reduced LDL cholesterol at a slightly lower dose (125 mg/day) in those with type 2 diabetes in a clinical trial of 48 people after 12 weeks. However, its unclear how clinically effective Pycnogenol is for most of these conditions due to the low quality of evidence. In another trial, 30 people with type 2 diabetes received a range of pycnogenol doses. WebMD does not provide medical advice, diagnosis or treatment. The combination of Panax ginseng and vitamin E also appears to have an effect. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. Pycnogenol seems well-tolerated for use in adults for up to 6 months. It is chronic venous insufficiency, a common disease among people who are obese or elderly and those who lead a sedentary lifestyle. Sort By. The study suggests it may increase desire, arousal, lubrication, orgasm, satisfaction and reduce pain [70]. Enzogenol, a slightly different pine bark extract, may help improve brain function after mild concussions. In a clinical trial of 92 people with tinnitus, or ringing in the ears, Pycnogenol (100-150 mg/day) helped reduce symptoms and improve blood flow in the ears after 4 weeks [80]. Infants and children may not be able to synthesize enough of it, but it is present in many protein-rich . In a clinical trial of 40 men with erectile dysfunction, 92.5% of the men on this combination regained normal erections after 3 months. Your email address will not be published. According to a study in 59 cancer patients, Pycnogenol (150 mg/day) may reduce side effects associated with radiation or chemotherapy, including mouth soreness and ulcers, mouth and eye dryness, nausea, vomiting, diarrhea and weight loss [78]. Pycnogenol, an extract of French maritime pine bark, helps the body fight normal aging by supporting vascular health and healthy circulation. According to some researchers, Pycnogenol may lower blood pressure by relaxing blood vessels, reducing free radicals, and lowering inflammation. Early research shows that taking it at least 5 weeks before the start of allergy season seems to lessen symptoms. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. Pycnogenol-treated patients had significant improvement in symptoms as well as a reduction in leg swelling as compared to those not receiving treatment. But did you know that pine bark extract, like pine oil, is one of natures super antioxidants? This article reviews tongkat ali, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. In those treated with Pycnogenol, the edema score was increased by 17.9% versus an increase of 58.3% in the control group. Finally, research suggests that Pycnogenol may improve triathlon time while possibly reducing cramps and post-running pain [10]. Importantly, all studies found that Pycnogenol has to be taken at least 5 weeks before the allergy season in order to see potential benefits, with the best results in those who take it 7-8 weeks ahead. So it may not be safe for people with immune disorders, such as: It's not known if pycnogenol is safe for children or for women who are pregnant or breastfeeding. (2015). 40 years of research has been dedicated to establishing the safety of Pycnogenol and its benefits for human health. The goal of this study was to evaluate if Pycnogenol could prevent deep venous thrombosis (DVT) and superficial vein thrombosis (SVT) in eight-hour flights in 196 subjects at risk of these conditions. With time, the participants were able to handle more UV radiation without experiencing skin damage [63]. A study of 147 people found that pycnogenol (100 mg/day) may improve running, push-ups, and sit-ups endurance in recreational athletes over an 8-week training program. Normalization of cardiovascular risk factors in peri-menopausal women with Pycnogenol [Abstract]. Pycnogenol also potentially improved cognitive function in 78 people with mild cognitive impairment. Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease caused primarily by tobacco use. (2012). Some people seek to manage ADHD symptoms through an ADHD diet. Pycnogenol may reduce glucose levels, but it doesnt appear to increase insulin production or insulin sensitivity. Mental function. Vertigo. DOI: Dvorkov M, et al. (3), Ototoxicity is ear poisoning and can occur when exposed to certain drugs or chemicals, such as cisplatin, that damage the inner ear or the vestibulocochlear nerve. Diindolylmethane, or DIM for short, is a plant indolea plant compound with health-promoting properties. It also may increase the activity of genes that make collagen and hyaluronic acid in the body [64]. A deficiency can cause issues like anemia, stunted growth, heart problems and neural tube defects. - Please read carefully and implement principles included in the Health Recovery Plan. Pycnogenol is considered safe when taken orally in a dose of 50 to 450 mg per day for one year. A trial of 86 people with eye damage from diabetes found that antioxidant therapy (including pycnogenol, vitamin E, and Coenzyme Q10) may improve eye health and reduce reactive oxygen species levels [35]. A 2021 review in the Arab Journal of Urology listed it first among "promising herbal remedies" for ED. Pycnogenol treatment resulted in more normal-looking sperm. Furthermore, when CHS was suppressed by 71% with exogenous treatment with cis-urocanic acid, the putative epidermal mediator of photoimmunosuppression, 0.2% Pycnogenol lotion reduced the immunosuppression to 18%. Taking pine bark extract supports healthy blood pressure. Take Helpful Supplements. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body . A trial of 84 people found that both Pycnogenol oral supplements and creams (0.5%) may prevent hemorrhoids from bleeding during acute attacks after 7 days. In mice, luteolin prevented inflammation and allergic response in the lungs and nose by inhibiting inflammatory cytokines: IL-4, IL-5, and IL-1 3 []. The first studied group included 66 healthy subjects in whom the number of muscle cramps was recorded two weeks before entering the study and during the fourth and fifth week. Ask your doctor for advice. Remember to speak with a doctor before taking Pycnogenol. More specifically, because it strengthens the capillaries in the retina, Mirtogenol can help prevent retinopathy. Another one of its exemplary effects is helping manage blood pressure levels. If you are thinking of taking Pycnogenol for a serious health condition like asthma or high blood pressure, check with your doctor., People who have autoimmune conditions like multiple sclerosis or lupus should talk to their doctor before trying Pycnogenol. In the placebo group, the retinopathy worsened; whereas, in the Pycnogenol-treated group, there was no deterioration. Talk to your own doctor about Pycnogenol if youre interested in using it for your own health. However, in all the above studies insulin levels did not change. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. There are also several other natural ADHD remedies you can try. Proper nutrition is essential for ADHD treatment. In another good study, 48 patients with diabetes and high blood pressure on ACE inhibitors were randomized to receive either Pycnogenol 125 mg daily or placebo for 12 weeks. Pine bark extract has been studied with regard to its ability to help diabetic patients. In long-haul flights, Pycnogenol could be an effective prevention for blood clots. According to a study of 11 patients with lupus, pycnogenol may reduce symptoms, inflammation, and oxidative stress [54]. $47.99. Plus, it reduced total and LDL (bad) cholesterol. Researchers suggest that Pycnogenol may reduce cough, night-awakenings, improve airway flow, and the need for additional asthma medication [16]. New studies show Pycnogenol can prevent or reverse the oxidative damage that produces blood vessel disease 4, metabolic syndrome 20, diabetes 20,24, and neurodegenerative disorders 23,24. It seems to lower blood pressure and improve blood flow to the legs. Lutein uses and benefits include helping prevent eye conditions like macular degeneration and cataracts, skin disorders and skin cancer, several types of cancer, including colon or breast cancer, type 2 diabetes, and heart disease. 1. ", American Heart Association: Understanding Blood Pressure Readings., Iranian Journal of Public Health: "Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis. It can also stabilize mast cells, which release histamine and trigger allergic reactions. Memorial Sloan-Kettering Cancer Center web site: "About Herbs: Pine Bark Extract. If youre wondering how to get an even skin tone, there are plenty of remedies that can help. Interactions. In another study, 45 men with ED were given 1.7 grams of L-arginine a day during the first month, 40 mg Pycnogenol twice daily during the second month, and the dose increased to three 40-mg Pycnogenol doses daily during the third month. More research is needed to see how this supplement affects all of these conditions. Researchers suggest this benefit may be due to an increase in glutathione and SOD, two antioxidants that may reduce inflammation and oxidative stress in Crohns [76]. Erectile dysfunction has increased over the past decade or two, creating a pathway for various medications to land on the shelves of numerous medicine cabinets. For most people, pine bark extract doesn't cause any side effects. Improve cardiovascular health. Are there any risks to taking it? Sign Up for the Latest Health News and Tips, Home Food and Nutrition Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies. Pycnogenol is the US trademarked name for an antioxidant made from Mediterranean tree bark. If possible, try to get pine bark extract from a local supplier, such as a health food store. . 2005 - 2023 WebMD LLC. A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75]. In a study of 72 children undergoing cancer chemotherapy, Pycnogenol reduced painful mouth ulcers, both alone and in combination with vitamin E [79]. Pycnogenol; Pycnogenol. A high number signals high blood pressure. Pycnogenol alleviated adverse effects in cancer patients, Pycnogenol improved working memory in older adults, Pycnogenol lowered the use of analgesic drugs in dysmenorrhea (severe menstrual pain), Pycnogenol reduced symptoms in endometriosis comparable to leuprorelin, the standard drug for this condition, Pycnogenol was found to be effective for sun-caused hyperpigmented skin, Pycnogenol reduced the inflammation in lupus patients, Pycnogenol reduced gingival bleeding and plaque formation. High-dose Pycnogenol (360 mg/day) for 4 weeks had the same LDL-lowering benefits in another study of 40 people [32, 56]. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Pycnogenol (100 mg/day) improved menopausal symptoms and quality of life in a clinical trial of 35 women after 8 weeks [68]. The results showed that the combination of local and systemic applications of Pycnogenol were the best in terms of ulcer healing even though local application of Pycnogenol also speeded up ulcer healing. Learn more about how to get even skin tone. Pycnogenol-treated subjects experienced an improvement in all menopausal symptoms. Headaches. chronic anal fissure may take more than 6 weeks to heal. Beta 1-3D Glucan is recognized by cells in the immune system, and can modify your immune system responses. She is a strong advocate of integrating scientific knowledge and holistic medicine. Typical doses range from 50 milligrams to 450 milligrams per day. Organika Pycnogenol 50mg 100 Tablets. Flavonoids and proanthocyanidins within these fruits can . According to a meta-analysis of 9 trials including 549 people, 150-200 mg/day for at least 12 weeks may reduce both diastolic and systolic blood pressure [36]. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. Although the preliminary studies show many health benefits with the use of Pycnogenol, future larger and better studies are needed. In this study, 155 peri-menopausal women were enrolled in a double-blind, placebo-controlled study. A study of 32 people with heart failure lasting 12 weeks suggests that a combination of Pycnogenol with CoQ10 (PycnoQ10) may improve blood pressure, heart function, edema, and capacity for physical activity [40]. In the following sections, well discuss the common forms and dosages of Pycnogenol that are commercially available. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. For people who have symptoms that are more severe, traditional medicine is probably more effective. It can also be used for local application on the skin without the risk of side effects. In 7 volunteers, Pycnogenol (300 mg) for 5 days may reduce the activity of a crucial inflammatory gene (NF-B) [53]. They include: We need more research to know for sure if pycnogenol helps treat these conditions. In a study of 61 ADHD children, pycnogenol reduced hyperactivity, improved attention, and motorics after 1 month. (1, 2). Pain score in the Pycnogenol-treated group was reduced by 56%, as compared to 9.6% reduction in the placebo group. Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. In the study, women taking Pycnogenol were more satisfied and compliant to the regimen [24]. Moreover, Pycnogenol lowered the chemical, leukotrienes responsible for asthma attacks. 5) Inflammation and Allergies. However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. You can learn more about how we ensure our content is accurate and current by reading our. While OPCs found in this extract are mostly known for their antioxidant-producing benefits, these amazing compounds exude antibacterial, antiviral, anticarcinogenic, anti-aging, anti-inflammatory and anti-allergic properties. There is limited evidence that it could be used in treating Attention Deficit Hyperactivity Disorder (ADHD). Pycnogenol reduced foot swelling in 79% of the patients, versus one percent in the placebo group. Score one for diabetes control and fewer risk factors for the heart. Grape seed extract may be more beneficial for those who are obese. The remaining compounds are phenolic acids, which may also have antioxidant activity [1, 2]. Pycnogenol has four main components that contribute to its benefits for men's health. In another trial, a combination supplement (Pycnogenol 60 mg/day, L-arginine 690 mg/day and aspartic acid 552 mg/day) improved erectile dysfunction and sexual satisfaction in men after 8 weeks. This bark extract has been around for about 450 years. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. New research shows . The combination of L-arginine and Pycnogenol may help in erectile dysfunction by boosting nitric oxide, which potentially could improve blood flow in men [66]. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Most have similar amounts of active substances and are often sold under the brand name Pycnogenol [6]. She loves communicating science and empowering people to achieve their optimal health. First and foremost, start eating an anti-inflammatory Local Raw Honey (Bee Pollen) Considering how good it tastes, having some raw honey Apple Cider Vinegar (ACV) You can now find high-quality apple cider vinegar in . Pycnogenol in metabolic syndrome and related disorders [Abstract]. Healthline Media does not provide medical advice, diagnosis, or treatment. returned. The study showed that many people who participated had a drop in their systolic blood pressure after taking Pycnogenol. It also seems to help with cell regeneration and replication. Pycnogenol is thought to be an antioxidant that helps protect cells from damage. High levels of both of these are considered risk factors for heart disease. You can refer to the National Institutes of Healths dosage guidelines for specific conditions. If you are taking blood thinners, do not take pine bark extract or Pycnogenol unless approved by your doctor. The dosage in most clinical studies varied between 50-360 mg/day. Today, I want to share with you my secrets to reduce sugar Top 7 Benefits of Green Tea: The No. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. Pycnogenol has been well-tolerated in most studies performed thus far. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body. Most anal fissures heal with home treatment after a few days or weeks. Pycnogenol has several benefits to your health and beauty. A study of 68 people found that Pycnogenol, started 2 days prior to flying, may reduce the duration of jet lag symptoms [83]. A review was conducted of French maritimepine bark extract, specifically using the nutritional supplement Pycnogenol. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25].