anti ccp levels 500 anti ccp levels 500

It remains possible that the disease may be present despite the . The Arthritis Foundation states that foods high in fiber can reduce the amount of C-reactive protein (CRP) in your blood. They are present in the majority of patients with rheumatoid arthritis. Kenilworth (NJ): Merck & Co. Inc.; c2020. Antibodies and autoantibodies are proteins made by the immune system. It can be a symptom of rheumatoid arthritis. This antibody which is produced by the immune system attacks the body. Some researchers feel that there is a strong connection between smoking and rheumatoid arthritis patients who have this shared epitope. They are never enough alone to diagnose RA. [12] Despite the excellent performance of these immunoassays, for example CCP-assays, they only provide a sensitivity comparable with that of rheumatoid factor (RF). September 2020 review byTheodore R. Fields, MD, FACP. In some cases, positive anti-CCP is an indication of other conditions aside from rheumatoid arthritis. 1-877-284-0235. The RASN is a non-profit team of healthcare professionals, and RA warriors who are committed to helping people with rheumatoid arthritis live full, happy lives despite their diagnosis. Washington D.C.: American Association for Clinical Chemistry; c20012020. Rheumatoid arthritis is not just a pain in your joints. Anti-CCP The daily pain, stiffness and swelling of rheumatoid arthritis can go undiagnosed for months causing permanent damage to your body. Chest X-ray showed a small right pleural effusion. when I get a cold it get a small flare up but other than that, I am able to play racquetball for a least 2 hours 6 days a week and can do regular activities (job, wife, kids, evening school, etc..). Pancreatic Elastase Stool Test Purpose, Procedure, Results, Normal Range, What is Cardiac Ablation? What Happens If CCP Antibody Is Positive? It may take 3-5 business days for full results to return. On the other hand, the presence of erosions at baseline predicted an increase in anti-CCP levels (+1.6 U/mL/mo, P =.008). doi: 10.1016/j.chembiol.2018.03.002. A blood sample is required for a CCP antibody test. The presence of autoantibodies against citrullinated proteins in rheumatoid arthritis patients was first described in the mid-1970s when the biochemical basis of antibody reactivity against keratin and filaggrin was investigated. Available from: Lab Tests Online [Internet]. This test which is conducted on RA patients is a prognostic tool to determine the severity of the problem. Smoking increases the risk of testing positive for anti-CCP antibody levels and is also associated with higher levels and more severe disease status in Rheumatoid Arthritis patients [10, 11, 12, 13]. Optimal Result: 0 - 19 Units. A positive result for cyclic citrullinated peptide (CCP) antibodies indicates a high likelihood of rheumatoid arthritis (RA). CCP positivity was quantified as low (level, 1-2 the upper limit of normal [ULN]), medium (2-3 ULN), or high (>3 ULN). The basis for determining the positive or negative anti-CCP result is 20 u/mL. The average cost of Anti-CCP test in India can be anywhere between Rs 500 to Rs 3000 depending on the city, quality, and the laboratory conducting the test. Pain so far is occasional but we'll see how it goes. The meaning of these results may depend on the results of a rheumatoid factor (RF) test as well as a physical exam. The anti CCP blood test is a rather new test that is becoming widely used, but the standardized RF test is generally ordered along with it or instead of it by many providers. Around 60% to 80% of people diagnosed with RA have anti-CCPs. RASN is dedicated to providing the most up to date and trusted information. Available from: University of Rochester Medical Center [Internet]. The CCP is an antibody that can indicate the presence of RA. When a patient is positive for Anti-CCP and RF, it is likely they have RA and may be more likely to have a more rapidly progressing and severe form of the disease. Do you all know of other sites for people with my similar issues?? anti-CCP is very specific of RA, but you can found them in other rjeumatic diseases: - Palindromic rheumatism: 56% (Salvador G. Rheumatology 2003;42:972) - Psoriatic arthritis; 12% (worse. Some labs report this sameresultusing a different measurement notation, that is, asless than 20EU/ml.) SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Leawood (KS): American Academy of Family Physicians; c2020. A person who manifests signs and symptoms of inflammatory arthritis is usually prescribed to undergo an anti-CCP blood test. A 2006 clinical study showed that anti viral citrullinated peptide (VCP) antibodies of the IgG and IgA isotypes represent a discriminating specific marker of rheumatoid arthritis from other chronic arthritides and disease controls, suggesting an independent production of each isotype. Anti-CCP antibodies were positive in 36/67 (54%) of those who had at least one erosion at inception, compared with 8/37 (22%) with non-erosive disease. Atlanta: Arthritis Foundation; Rheumatoid Arthritis; [cited 2020 Feb 12]; [about 3 screens]. The cost to maintain this website grows each week. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at support@selfdecode.com. . This may also occur in the feet, knees, hip,s elbows, shoulder, or the neck. More Information Juvenile idiopathic arthritis Epub 2014 Jul 3. These include x-rays of your joints and the following blood tests: These blood tests can show signs of inflammation. These patients are considered to have "seronegative rheumatoid . Research has shown that rheumatoid arthritis patients who test positive for anti-CCP could potentially experience a more aggressive set of symptoms and more severe damage to the affected joints. . As well, it. Rheumatoid arthritis is first and foremost a clinical diagnosis. There is very little risk to having a blood test. I was just diagnosed with RA. This typically occurs when there are painful and warm wrist and hand joints. but is for informational and educational purposes alone. This marker can indicate the level of inflammation in your body. Rheumatoid factors are another type of autoantibody. The specific cause of developing anti-CCP antibodies in patients is unknown. all my numbers look normal except my CCP Antibody IgG is > 500 (where they same normal range is < 16). A level above 20 suggests the possibility of RA. If the result is lower than 20 u/mL, you are positive for anti-CCP, but if the result is 20 u/mL or higher, you are negative for anti-CCP. If the test results indicate the presence of RF without CCP antibodies, there are antibodies without RF, or both are present but in low levels, then this may be an indication of early RA. The test is also known as an anti-citrulline antibody, cyclic citrullinated peptide antibody (CCPA), anti-cyclic citrullinated peptide antibody, and anti-CCP. When it is positive, there is a 90 to 95 percent likelihood that the person has RA. Tilvawala R, Nguyen SH, Maurais AJ, Nemmara VV, Nagar M, Salinger AJ, Nagpal S, Weerapana E, Thompson PR. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Hello. Joint Bone Spine. That is to say: the following substances have been found to decrease both inflammation and, by proxy, anti-CCP levels. [13][14] Unfortunately, these artificial antigens are not expressed in the affected tissue, and therefore are probably not directly involved in the pathogenesis of RA. If your test report suggests reading more than 20 u/ml, you are likely to be positive for rheumatoid arthritis. The normal level of anti-CCP is less than 20 Units. It is possible to have an autoimmune disorder like rheumatoid arthritis and have a negative anti CCP blood test. In July 2010, the 2010 ACR/EULAR Rheumatoid Arthritis Classification Criteria were introduced. To help in diagnosing rheumatoid arthritis, Why Fasting Is Required Before Blood Test, Right Side Abdominal Pain Symptoms, Causes, Diagnosis, Treatment, Left Side Abdominal Pain Symptoms, Causes, Diagnosis, Treatment. Anti-cyclic citrullinated peptide (anti-CCP) is an antibody present in most rheumatoid arthritis patients. [4][5] Subsequent studies demonstrated that autoantibodies from RA patients react with a series of different citrullinated antigens, including fibrinogen, deiminated Epstein-Barr Virus Nuclear Antigen 1 and vimentin,[6][7][8] which is a member of the intermediate filament family of proteins. Below are the normal measurements in our lab other labs may well have their own set of normal values. The RF isotype will be established using the routine method and the results of anti-CCP and RF plasma levels are already known and this information is available in the patients files. Available from: HSS [Internet]. The aim of the present study was to determine whether the antiCCP antibody was present in patients with psoriasis with and without arthritis. Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E, et al. This means that the patients immune system produces antibodies that identify the patients cells as foreign material and as a result, attack its own normal cells. all my numbers look normal except my CCP Antibody IgG is > 500 (where they same normal range is < 16). CCP Antibodies IgG/IgA. The reason for this is RF is present in patients without rheumatoid arthritis who have other autoimmune disorders. Rheumatoid Arthritis (RA); 2019 Feb [cited 2020 Feb 12]; [about 2 screens]. There is no indication of whether these strategies might directly reduce anti-CCP. However, this can also depend on many different factors and varies between each individual. The normal range of RF is from 0-20 IU/ml. Glossary: Cyclic citrullinated peptide (CCP) antibody test; [cited 2020 Feb 12]; [about 3 screens]. If the test results indicate the presence of RF without CCP antibodies, there are antibodies without RF, or both are present but in low levels, then this may be an indication of early RA. Your provider may order one or more tests in addition to CCP antibody and RF tests. If your results are negative for both tests (anti-CCP and RA), it is likely that the arthritis is due to a cause other than rheumatoid arthritis. (At Hospital for Special Surgery, anti-CCP is reported in Units. In Figure 4a-c, the self-assembled layer of the fiber was photographed using magnifications of 500, 4000, and 5000, respectively. Despite these rare cases, a positive anti-CCP test is considered highly specific to rheumatoid arthritis (meaning a negative test does not rule out the disease, but a positive result rules it in). Testing for the presence of anti-CCP is a relatively new support tool in helping doctors diagnose rheumatoid arthritis. Remember that this is just the beginning. 12922961. Anti-CCP is commonly produced when you have rheumatoid arthritis. These include: You may also need this test if other tests couldn't confirm or rule out a diagnosis of rheumatoid arthritis. What is the reference range for anti cyclic citrullinated peptide? It also helps in prognosticating aggressive joint erosion. When there are the signs and symptoms of arthritis present, then the anti CCP blood test may be ordered to eliminate or confirm the possibility of rheumatoid arthritis. Rheumatoid arthritis is a progressive, autoimmune disease that causes pain, swelling, and stiffness in the joints. A CCP antibody test requires a blood sample. Some people with RA will have negative rheumatoid factor and negative anti-CCP. If you continue to use this site we will assume that you are happy with it. Positive CCP antibodies and positive RF, it likely means that you have rheumatoid arthritis. [21] Novel assays may be useful for monitoring disease activity and effects of RA therapy.[22]. Anti-CCPs can also exist in a patient for years before they ever develop clinical rheumatoid arthritis symptoms. Other conditions such as psoriatic arthritis, lupus, and hepatitis c can also cause elevations in anti ccp. It's a newer, much more accurate test. However, data from all around the world vary substantially. Perhaps you need to be on other medicines for this condition. Also, the stimulating effects of caffeine help to fight physical and mental fatigue that is common with rheumatoid arthritis. These attacks can produce inflammatory symptoms most commonly experienced in rheumatoid arthritis. Available from. CCP antibodies, also called anti-CCP antibodies, are a type of antibody called autoantibodies. These symptoms must also occur for more than six consecutive weeks and meet certain criteria such as how many joints are involved and where they are located on the body. Studies show that in anti-CCP positive patients, higher levels of omega-3s slowed the progression of inflammatory arthritis symptoms, but further study is needed [20, 22]. Your email address will not be published. At 20u/mL and higher, an anti-CCP test is considered positive and, with other symptoms and factors, is usually a sign of rheumatoid arthritis. The meaning of these results may depend on the results of a rheumatoid factor (RF) test as well as a physical exam. (At Hospital for Special Surgery, anti-CCP is reported in Units. 2018 Jun 21;25(6):691704.e6. Other blood tests are also performed in conjunction with the anti-CCP test, including testing for rheumatoid factor (RF) antibodies and increased inflammation levels. When a doctor tests for RF levels, they may also perform an anti-CCP test. The anti-CCP Master curve material (Siemens Healthineers) with 5 preassigned levels of 0.4, 45, 90, 135, and 180 U/mL was tested in duplicate, and the linearity was evaluated by comparing against expected concentrations calculated from the linear fit and statistically best polynomial fit. Other testing is performed to help exclude the possibility that lupus could be causing the bothersome symptoms instead of rheumatoid arthritis. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. A positive anti-CCP test result can be used in conjunction with other blood tests, imaging tests, and/or physical examination findings to diagnose rheumatoid arthritis. Test Result Name. Anti-cyclic citrullinated peptide (anti-CCP): the doctor will draw a blood test to run Anti-CCP. We use cookies to ensure that we give you the best experience on our website. Enter a Melbet promo code and get a generous bonus, An Insight into Coupons and a Secret Bonus, Organic Hacks to Tweak Audio Recording for Videos Production, Bring Back Life to Your Graphic Images- Used Best Graphic Design Software, New Google Update and Future of Interstitial Ads. Anti-CCP positive testing is also used to help doctors deliver a prognosis because many anti-CCP positive patients experience severe rheumatoid arthritis symptoms. Doctor of Medicine (M.D.) Both ESR and C-reactive protein are non-RA-specific measures of inflammation. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Autoantibodies can cause disease by attacking the body's healthy cells by mistake. Anticyclic citrullinated peptide (anti-CCP) antibody levels are characteristically elevated in rheumatoid arthritis, although they can be elevated in other rheumatologic conditions associated with inflammatory arthritis, such as systemic lupus erythematosus. Anti-MCV levels in the cases . Vimentin, fibrin, filaggrin, enolase and keratin are common citrullination targets. CCP antibodies are produced by the immune system and can mistakenly attack healthy tissues. All rights reserved. Anti-CCP is a blood test. Anti-CCP is an autoantibody. 2014 Oct;81(5):41620. Whether anti-CCP levels may change during treatment according to clinical response is matter of debate. Reference range. Furthermore, a positive anti-CCP does not necessarily mean a diagnosis of rheumatoid arthritis. The pain will eventually result in joint deformity and bone erosion. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. doi: 10.1016/j.jbspin.2014.06.001. If CCP antibodies are found in your blood, it can be a sign of rheumatoid arthritis. A CCP antibody test requires a blood sample. It typically is higher in the joints of people with Rheumatoid Arthritis ( RA) Given the high number it's possible this person has RA. Diagnosing rheumatoid arthritis at its earliest stages can prevent damage and improve long-term quality of life. 4 What is the normal range for an anti CCP blood test? Production of anti-citrullinated protein antibodies (ACPAs) is an important biomarker for rheumatoid arthritis (RA). Orlando (FL): Rheumatoid Arthritis Support Network; RA and Anti-CCP: What is the Purpose of an Anti-CCP Test? Rheumatoid arthritis is a clinical diagnosis. An anti-CCP test is considered positive if it is above 20 units. [6][17] Noteworthy are the findings of a recently published study that highly valuates anti-MCV test systems for diagnosing rheumatoid arthritis in anti-CCP-negative patients. The CCP (cyclic citrullinated peptide) blood test is ordered with a number of other tests to determine what an individuals rheumatoid factor happens to be. Natural Factors That May Decrease Inflammation in Joint Disease 2003 Sep;62(9):870-874. [18] Anti-CCP is also very useful in the early diagnosis of rheumatoid arthritis in high-risk groups, such as relatives of RA patients,[19] although Silman and co-workers found that the concordance rate of developing RA was 15.4% among identical (monozygotic) twins and was 3.6% among fraternal (dizygotic) twins. After a mean follow-up of 47.3 20.8 months, only one PMR patient developed RA; this patient was seronegative for both RF and anti-CCP Abs. Los anticuerpos nos protegen de las enfermedades combatiendo sustancias extraas como los virus y las bacterias. Both tests are used to test disease activity; when they are high,this suggests that the disease is very active (assuming no other causes for high results, such as infection, are present). Be sure to tell your health care provider about all medicines, vitamins, and dietary supplements you are taking. . Required fields are marked *. Omega-3 fats help by reducing inflammation that can increase the citrullination of proteins leading to an immune system reaction and increased anti-CCP [20, 21]. CCP. 5 Reducing inflammation in the body could help reduce joint pain. Cleveland (OH): Cleveland Clinic; c2020. Every medical provider treats the diagnostic process toward rheumatoid arthritis a little differently. Citrullinated vimentin is a very promising autoantigen in RA, and a suitable tool for studying this systemic autoimmune disease. We do not aim to diagnose, treat, cure or prevent any illness or disease. Negative results may not necessarily mean the lack of a disease or disorder either. Hemoglobin and albumin levels were lower in the anti-CCP-positive group than in the anti-CCP/RF-negative group and . These antibodies are made as a direct attack of specific proteins found naturally in the body. What is considered a high anti-CCP level? Anti-CCP positive rheumatoid arthritis patients generally receive the most aggressive treatment options available including taking disease-modifying antirheumatic drugs (DMARDs) and supplementing withanti-inflammatory home remedies to provide symptom relief. Based on his own health success, he went on to found SelfDecode, the worlds first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Dental treatment that removed P. gingivalis reduced the production of citrulline in 55 RA patients [3]. my arthritis pain is VERY low. Anti-citrullinated protein antibodies (ACPAs) are autoantibodies (antibodies to an individual's own proteins) that are directed against peptides and proteins that are citrullinated. You may need to stop taking certain substances for 8 hours before your test. Whats the normal range for an anti CCP test? I've been on 400 Hydroxychloroquine and 6 tablets mtx since last year. Re-testing later on may be required in patients who continue to display clinical rheumatoid arthritis symptoms. It is common to experience higher levels of fatigue and a fever. The Anti-CCP Test Procedure is just easy. Combination of anti-CCP with other serological markers like rheumatoid factor, 14-3-3 (YWHAH) not only enhances the diagnostic capture rate but together with acute phase reactants either in early disease or at the time of diagnosis may be useful in predicting future outcomes. . Learn more here. This test is 97% specific for RA if it is present. Anti-CCP Abs are considered of special interest in the diagnosis of seronegative RA. Anti-CCP or Anti-Cyclic Citrullinated Peptide is an autoantibody also known as ACPAs or anti-citrullinated protein antibodies. Applies only to results expressed in units of measure originally reported by the performing laboratory. The anti CCP blood test is a rather new test that is becoming widely used, but the standardized RF test is generally ordered along with it or instead of it by many providers. Your email address will not be published. This includes a complete blood count, synovial fluid testing, and ANA blood tests. If the sample finds the presence of anti-CCP at a certain level, the result is positive. A positive outlook depends on early detection of symptoms followed by a diagnosis. While a high CCP may mean a possibly aggressive disease course, it must be looked at with the amount of swelling, inflammation in the blood, and the number of joints involved. A level above 20 suggests the possibility of RA. Omega-3 fats help by reducing inflammation that can increase the citrullination of proteins leading to an immune system reaction and increased anti-CCP [20, 21]. The patient also needs to have a clear manifestation of rheumatoid arthritis symptoms, and such should occur for more than six weeks. A positive anti-CCP usually means that you have rheumatoid arthritis. Cyclic Citrullinated Peptide Antibody; [updated 2019 Dec 24; cited 2020 Feb 12]; [about 2 screens]. Alternatively, a patient with similar symptoms but negative blood work is referred to as having seronegative rheumatoid arthritis. Some researchers believe that the shared epitope is what attaches to these proteins and produces the anti-CCP antibodies. Joe is a thriving entrepreneur, with a mission to empower people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time. However anti-CCP is not associated with extraarticular features (unlike RF) variation of levels with treatment of RA. CCP antibodies, also called anti-CCP antibodies, are a type of antibody called autoantibodies. Objectives: Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a serological marker of rheumatoid arthritis (RA), and also have a prognostic value for more aggressive disease. [3] These new classification criteria include ACPA testing, and overruled the "old" ACR criteria of 1987 and are adapted for early RA diagnosis. Some research suggests that oral bacteria such as P. gingivalis directly contribute to the development of rheumatoid arthritis [9]. It is a blood test that can help you identify the presence of antibodies which causes rheumatoid arthritis. Anti-CCP is an antibody which can be detected by anti CCP blood test and other blood tests, physical examinations, and imaging tests. The Fortune 500 should take note. Ann Rheum Dis. 14-3-3: a novel biomarker platform for rheumatoid arthritis. serum IgM-RF and less so anti-CCP oc - curred in RA patients treated with anti-TNF, however, DAS28 after 24 weeks could again not be predicted by these changes in autoantibody levels (18). Niewold TB, Harrison MJ, Paget SA. ACPAs have proved to be powerful biomarkers that allow the diagnosis of rheumatoid arthritis (RA) to be made at a very early stage. Anti-CCP: Anti-Cyclic Citrullinated Peptide Antibody Also known as Anti-Citrullinated Protein Antibody (ACPA) Useful in diagnosis and prognosis of rheumatoid arthritis (RA) Newest anti-CCP assay yields a specificity of 98%, the sensitivity of 80% for RA Present in 70% of patients with established RA What is Anti-CCP? Autoantibodies; [updated 2019 Nov 13; cited 2020 Feb 12]; [about 3 screens]. It is fairly common to have a general feeling of not being well if rheumatoid arthritis is present as well. Cyclic citrullinated peptide (CCP) antibody testing detects and measures CCP antibodies in the blood. https://labtestsonline.org/understanding/analytes/ccp/tab/test/, http://www.arthritisandpainclinic.com/blood-tests.html, http://arthritis.about.com/od/radiagnosis/f/anticcp.htm, http://www.webmd.com/rheumatoid-arthritis/arthritis-test-results, http://www.medicinenet.com/citrulline_antibody/index.htm, http://patient.info/doctor/rheumatoid-arthritis-pro, http://www.arthritis.org/about-arthritis/types/rheumatoid-arthritis/articles/what-type-do-you-have.php, http://rheumatology.oxfordjournals.org/content/43/5/655.full, http://ard.bmj.com/content/64/10/1521.full.pdf. Original summary written by Lysa Petrsoric, MPH, MSW, April 20, 2015, and edited by Nancy Novick. I'm 29, I was diagnosed with RA about. The joint is usually stiff in the morning, but will begin to loosen up during the rest of the day. For this reason, only a medical provider will be able to interpret individualized test results and compare them with symptoms to determine a diagnosis. A Mayo prospective clinical evaluation of the CCP antibody test showed a diagnostic sensitivity for RA of 78% with fewer than 5% false positive results in healthy controls (see Cautions). These antibodies can be detected in as little as 3 months in individuals who have developed a high rheumatoid factor. What does a positive Anti-CCP test result mean? Smoking increases the citrullination of proteins that can trigger an autoimmune reaction [14]. The normal measurement is less than 1.0 in many labs. Available from: Merck Manual Consumer Version [Internet]. When RF serostatus (yes/no) was included in the model instead of anti-CCP serostatus, no association with osteopenia in femoral neck/ward was found (data not shown). If anything fails to meet your standards in any way please contact us so that we may consider removing it from our recommendations. Positive CCP antibodies and positive RF, it likely means that you have rheumatoid arthritis. This test is used to diagnose or rule out rheumatoid arthritis and to assess its possible severity . Antibodies protect you from disease by fighting foreign substances like viruses and bacteria. Since her cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor tests were positive, rheumatoid arthritis (RA) was diagnosed and she was started on prednisone with plans for additional disease modifying therapy. Rheumatoid Arthritis: Diagnosis and Tests; [cited 2020 Feb 12]; [about 4 screens]. Available from: Lab Tests Online [Internet]. Negative levels do not exclude the disease, and positive levels do not guarantee the diagnosis. One study of 127 rheumatoid arthritis patients looked at the effect of taking sweet wormwood (Artemisia annua) or a placebo in addition to standard immunosuppressive drugs. High levels of CCP antibodies have also been discovered in connective tissue diseases, autoimmune disorders, and particularly with some forms of lupus. We keep the number of high qualtiy advertisers very low. In case studies, higher omega-3 fatty acid levels are associated with a lower risk of anti-CCP antibody production [18, 19]. In a study of over 200 people, lower vitamin D levels were linked to higher anti-CCP antibody levels [17]. Moreover, analysis of the correlation of anti-CCP antibody titre with RA disease activity yielded conflicting results. Mayo Foundation for Medical Education and Research; c19952020. (Autoantibodies develop in response to the bodys own tissue, and are characteristic of autoimmune diseases, such as RA.) CCP testing was performed mainly to evaluate patients with joint pain. [Also Read: Why Fasting Is Required Before Blood Test]. If so, then you will be given the appropriate treatment for rheumatoid arthritis. Vitamin D may help lower anti-CCP antibodies by suppressing overactive immune cells that attack the bodys own proteins and tissues [17]. Hello: my CCP has climbed up in the past year from ~25 to ~77 to ~147. It is calculated by measuring the rate at which red blood cells sediment in a test tube in one hour. is a clickable link to peer-reviewed scientific studies.